Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ifngr1tm1.1Rost
Name:	interferon gamma receptor 1; targeted mutation 1.1, Robyn Starr
MGI ID:	MGI:4361521
Synonyms:	Ifngr1441F
Gene:	Ifngr1  Location: Chr10:19467697-19485977 bp, + strand  Genetic Position: Chr10, 8.49 cM
Alliance:	Ifngr1tm1.1Rost page

Germline Transmission:	Earliest citation of germline transmission: J:152785
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Single point mutation   Mutation details: Exon 7 contains a nucleotide substitution (TAT -> TTT) that results in the amino acid substitution of tyrosine with phenylalanine at position 441 (Y441F). A downstream floxed neo was removed by germ line, cre mediated recombination. The mutated amino acid is within the Socs1 binding site. (J:152785)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ifngr1 Mutation:	52 strains or lines available

Original:	J:152785 Starr R, et al., SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo. J Immunol. 2009 Oct 1;183(7):4537-44
All:	1 reference(s)