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Klf6tm1Fjs
Targeted Allele Detail
Nomenclature
Symbol: Klf6tm1Fjs
Name: Kruppel-like factor 6; targeted mutation 1, Frederic J de Sauvage
MGI ID: MGI:4361337
Synonyms: Klf6f
Gene: Klf6  Location: Chr13:5911488-5920392 bp, + strand  Genetic Position: Chr13, 2.94 cM, cytoband A1
Abnormality in ductal branching in the Klf6tm1Fjs/Klf6tm1Fjs Nkx3-1tm3(cre)Mms/Nkx3-1+ prostate epithelium

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:153183
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed, reverse orientation neo cassette was inserted into intron 1 and a single laxP site was inserted into intron 3 via homologous recombination. (J:153183)
Generation of the Klf6tm1Fjs allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf6 Mutation:  12 strains or lines available
References
Original:  J:153183 Leow CC, et al., Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. J Biol Chem. 2009 Jul 31;284(31):21057-65
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/05/2021
MGI 6.17
The Jackson Laboratory