Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lrrk2tm1.1Shn
Name:	leucine-rich repeat kinase 2; targeted mutation 1.1, Jie Shen
MGI ID:	MGI:4356349
Synonyms:	Lrrk2R1441C
Gene:	Lrrk2  Location: Chr15:91557378-91700323 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Alliance:	Lrrk2tm1.1Shn page

Germline Transmission:	Earliest citation of germline transmission: J:151944
Parent Cell Line:	MKV6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129)F1

Allele Type:    Targeted (Humanized sequence) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Exon 31 was replaced with one in which nucleotide substitutions led to the amino acid substitution of cysteine for arginine at position 1441 (R1441C), mimicking a mutation found in xome Parkinson's disease patients. A floxed neo cassette was inserted downstream of the modified exon and removed by transient cre expression in ES cells. (J:151944)

Generation of the Lrrk2tm1.1Shn allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lrrk2 Mutation:	156 strains or lines available

Original:	J:151944 Tong Y, et al., R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14622-7
All:	11 reference(s)