Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il10tm1.1Karp
Name:	interleukin 10; targeted mutation 1.1, Christopher L Karp
MGI ID:	MGI:4355198
Synonyms:	Il10gfp, Vert-X
Gene:	Il10  Location: Chr1:130947582-130952711 bp, + strand  Genetic Position: Chr1, 56.89 cM
Alliance:	Il10tm1.1Karp page

Germline Transmission:	Earliest citation of germline transmission: J:151551
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Reporter) Mutation:    Insertion   Mutation details: A floxed neomycin cassette and an IRES- eGFP cassette was cloned into the HindIII site between the endogenous stop and poly(A) sites of the gene locus. The neomycin cassette was subsequently removed by breeding founder mice with cre-transgenic mice. The targeted locus expressed both the endogenous gene and the reporter gene in activated homozygous B cells as determined by ELISPOT analysis on GFP+ cells. (J:151551)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il10 Mutation:	44 strains or lines available

Original:	J:151551 Madan R, et al., Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol. 2009 Aug 15;183(4):2312-20
All:	77 reference(s)