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Tead2tm1.1Mldp
Targeted Allele Detail
Nomenclature
Symbol: Tead2tm1.1Mldp
Name: TEA domain family member 2; targeted mutation 1.1, Melvin DePamphilis
MGI ID: MGI:3763367
Synonyms: Tead2-
Gene: Tead2  Location: Chr7:45215753-45233636 bp, + strand  Genetic Position: Chr7, 29.19 cM, cytoband B5
Exencephaly in Tead2tm1.1Mldp/Tead2tm1.1Mldp embryos at E13.5

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127233
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe enhancer located upstream of exon 2, exon 2 and exon 3 were removed by cre-mediated recombination. These regions are responsible for encoding the N-terminal 99 amino acids of the protein thereby removing the translation initiation site and 82% of the TEA domain. Reduction in transcript production was confirmed by northern blot analysis on RNA extracted from lungs. (J:127233)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tead2 Mutation:  20 strains or lines available
References
Original:  J:127233 Kaneko KJ, et al., Transcription factor TEAD2 is involved in neural tube closure. Genesis. 2007 Sep;45(9):577-87
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory