Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Gja1tm7(Gja2)Kwi Name: gap junction protein, alpha 1; targeted mutation 7, Klaus Willecke MGI ID: MGI:3763136 Synonyms: Cx4326 Gene: Gja1  Location: Chr10:56253297-56266519 bp, + strand  Genetic Position: Chr10, 28.64 cM Alliance: Gja1tm7(Gja2)Kwi page

Tubuli seminiferi and ductuli epididymidis of wild type and Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:126511
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted Mutations:    Insertion, Intragenic deletion   Mutation details: The open reading frame was replaced with that of Gja2 and a neo cassette flanked by FRT sites. The neo cassette was subsequently removed by Flp-mediated recombination following a cross to Tg(ACTFLPe)9205Dym mice. The replacement of protein products was confirmed by western blot analysis on protein extracts from heart lysates. (J:126511)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gja1 Mutation:	59 strains or lines available

Original:	J:126511 Winterhager E, et al., Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart. BMC Dev Biol. 2007;7:26
All:	1 reference(s)