Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Aiapy
Name:	nonagouti; intracisternal A particle yellow
MGI ID:	MGI:1856403
Synonyms:	A*
Gene:	a  Location: Chr2:154792519-154892932 bp, + strand  Genetic Position: Chr2, 76.83 cM
Alliance:	Aiapy page

Strain of Origin:

(C57BL/6J x C3H/HeJ)F1/J

Allele Type:    Spontaneous Mutation:    Transposon insertion   Mutation details: Southern blot analysis showed that this allele is the result of a 5.2 kb intracisternal A particle (IAP) transposon insertion in an antisense orientation immediately 5' of the first coding exon of the agouti gene. This results in ectopic and differential expression of agouti protein via utilization of a cryptic promoter within the IAP 5' long terminal repeat (LTR) and variable methylation. Methylation assay results indciate that the agouti and yellow mosaic phenotype characteristic of this allele is due to differential epigenetic methylation of the IAP. mRNA from this allele was found to be ectopically over-expressed in several adult tissues from heterozygous mice. The transcript was the same size as mRNA from the wild-type allele. The mutation occurred in a C3H/HeJ A allele. (J:18848, J:21244, J:79708) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any a Mutation:	463 strains or lines available

Original:	J:18848 Michaud EJ, et al., Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage. Genes Dev. 1994 Jun 15;8(12):1463-72
All:	5 reference(s)