Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bmp4tm1.1Jlch
Name:	bone morphogenetic protein 4; targeted mutation 1.1, Jan L Christian
MGI ID:	MGI:3714059
Synonyms:	Bmp4S2G
Gene:	Bmp4  Location: Chr14:46620982-46628126 bp, - strand  Genetic Position: Chr14, 23.95 cM
Alliance:	Bmp4tm1.1Jlch page

Germline Transmission:	Earliest citation of germline transmission: J:108516
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted Mutation:    Insertion   Mutation details: Mutant mice carrying the Bmp4tm1Jlch allele were crossed with transgenic mice expressing Cre under the control of the CMV promoter, removing the neomycin resistance cassette in the germ line, leaving the two point mutations in exon 4 and a single loxP site downstream of exon 4. (J:108516)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmp4 Mutation:	21 strains or lines available

Original:	J:108516 Goldman DC, et al., Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity. Development. 2006 May;133(10):1933-42
All:	4 reference(s)