Ncf4tm2Pth
Targeted Allele Detail
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| Symbol: |
Ncf4tm2Pth |
| Name: |
neutrophil cytosolic factor 4; targeted mutation 2, Phillip T Hawkins |
| MGI ID: |
MGI:3712357 |
| Synonyms: |
P40phox- |
| Gene: |
Ncf4 Location: Chr15:78129001-78146780 bp, + strand Genetic Position: Chr15, 37.1 cM
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| Alliance: |
Ncf4tm2Pth page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:121820
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Inserted expressed sequence, Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: A translational stop codon was introduced at codon 73 in exon 3 in the targeting vector. The vector also contains both a tACE-Cre and neoR module. Recombination in ES cells introduced the stop codon into the Ncf4 sequence. When chimeras were bred, tACE promoter activity in testes promoted Cre/loxP-mediated deletion of the cassette, leaving 59 bp of foreign DNA. No Ncf4 protein can be detected by antibodies in homozygous mice.
(J:121820)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ncf4 Mutation: |
23 strains or lines available
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| Original: |
J:121820 Ellson CD, et al., Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J Exp Med. 2006 Aug 7;203(8):1927-37 |
| All: |
12 reference(s) |
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Analysis Tools
