Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tcrbtm3Che
Name:	T cell receptor beta chain; targeted mutation 3, Jianzhu Chen
MGI ID:	MGI:3708170
Synonyms:	Vbeta(neo)
Gene:	Tcrb  Location: Chr6:40868230-41535305 bp, + strand  Genetic Position: Chr6, cytoband A-C

Germline Transmission:	Earliest citation of germline transmission: J:120387
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted Mutation:    Insertion   Mutation details: The Vbeta13 gene segment with its endogenous promoter and recombination signal sequences and a floxed pgk-neomycin resistance cassette is inserted upstream of the D segment. Insertion was confirmed by Southern blot analysis of ES cells and by increased expression of Vbeta13 T cells in homozygous mice. (J:120387)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcrb Mutation:	94 strains or lines available

Original:	J:120387 Sieh P, et al., Distinct control of the frequency and allelic exclusion of the V beta gene rearrangement at the TCR beta locus. J Immunol. 2001 Aug 15;167(4):2121-9
All:	1 reference(s)