Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mesp2tm8Ysa
Name:	mesoderm posterior 2; targeted mutation 8, Yumiko Saga
MGI ID:	MGI:3707530
Synonyms:	3xFLAG-Mesp2delta326-330, F-Mesp2deltaD
Gene:	Mesp2  Location: Chr7:79460475-79463179 bp, + strand  Genetic Position: Chr7, 45.18 cM
Alliance:	Mesp2tm8Ysa page

Germline Transmission:	Earliest citation of germline transmission: J:119678
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Hypomorph) Mutation:    Insertion   Mutation details: These mice express the FLAG-tagged locus lacking amino acids 326-330, which comprise the degredation domain. A floxed neo included in the vector was subsequently removed via cre mediated recombination. Expression of the mutant transcript was similar to wild type in localization, however, levels were lower. Likewise, protein expression was lower, demonstrating that the allele is a hypomorph. Western blot confirmed absence of wild-type protein in mutants. (J:119678)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mesp2 Mutation:	30 strains or lines available

Original:	J:119678 Morimoto M, et al., Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis. Dev Biol. 2006 Dec 15;300(2):687-98
All:	1 reference(s)