Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lhx6tm2Vpa
Name:	LIM homeobox protein 6; targeted mutation 2, Vassilis Pachnis
MGI ID:	MGI:3702518
Synonyms:	Lhx6-, Lhx6tm2Pach
Gene:	Lhx6  Location: Chr2:35971965-35995420 bp, - strand  Genetic Position: Chr2, 24.17 cM
Alliance:	Lhx6tm2Vpa page

Germline Transmission:	Earliest citation of germline transmission: J:119476
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 through 4 and part of exon 5 were replaced with an IRES-eGFP and a floxed PGK-neo cassette. The neo cassette was then removed in vivo by Cre-mediated recombination. Immunohistochemistry and western blot analysis confirmed near total loss of protein expression in homozygous mice. No GFP expression is seen in heterozygotes. (J:119476)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	46 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lhx6 Mutation:	27 strains or lines available

Original:	J:119476 Liodis P, et al., Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci. 2007 Mar 21;27(12):3078-89
All:	6 reference(s)