Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Esr1tm1Gsc
Name:	estrogen receptor 1 (alpha); targeted mutation 1, Gunther Schutz
MGI ID:	MGI:3696669
Synonyms:	ERalphaflox
Gene:	Esr1  Location: Chr10:4561989-4955633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Alliance:	Esr1tm1Gsc page

Germline Transmission:	Earliest citation of germline transmission: J:117231
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 3 was flanked by loxP sites. An frt-flanked neo inserted just downstream of the exon was subsequently removed via transient expression of Flp recombinase. (J:117231)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:	67 strains or lines available

Original:	J:117231 Wintermantel TM, et al., Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron. 2006 Oct 19;52(2):271-80
All:	9 reference(s)