Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pde3btm1Yhc
Name:	phosphodiesterase 3B, cGMP-inhibited; targeted mutation 1, Young Hun Choi
MGI ID:	MGI:3696665
Synonyms:	Pde3b-
Gene:	Pde3b  Location: Chr7:114014388-114137173 bp, + strand  Genetic Position: Chr7, 59.46 cM
Alliance:	Pde3btm1Yhc page

Germline Transmission:	Earliest citation of germline transmission: J:117353
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace a 600 bp part of exon 1, including the ATG, with a neomycin resistance cassette. (J:117353)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pde3b Mutation:	43 strains or lines available

Original:	J:117353 Choi YH, et al., Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. J Clin Invest. 2006 Dec;116(12):3240-51
All:	10 reference(s)