Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabra4tm1.1Geh
Name:	gamma-aminobutyric acid type A receptor subunit alpha 4; targeted mutation 1.1, Gregg E Homanics
MGI ID:	MGI:3691194
Synonyms:	alpha4 KO, f, GABARalpha4
Gene:	Gabra4  Location: Chr5:71727092-71815651 bp, - strand  Genetic Position: Chr5, 38.08 cM
Alliance:	Gabra4tm1.1Geh page

Germline Transmission:	Earliest citation of germline transmission: J:115154
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 3 was removed via cre mediated recombination. Absence of protein was demonstrated in hippocampus, thalamus and cortex by Western blot analysis. (J:115154)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabra4 Mutation:	42 strains or lines available

Original:	J:115154 Chandra D, et al., GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15230-5
All:	16 reference(s)