Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Acvrl1tm1Dyl
Name:	activin A receptor, type II-like 1; targeted mutation 1, Dean Y Li
MGI ID:	MGI:2155981
Synonyms:	Alk1-
Gene:	Acvrl1  Location: Chr15:101026403-101043217 bp, + strand  Genetic Position: Chr15, 56.41 cM, cytoband F3
Alliance:	Acvrl1tm1Dyl page

Germline Transmission:	Earliest citation of germline transmission: J:65521
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Not Specified   Mutation details: The mutation disrupted trancriptional and translational initiation. No specific molecular details were described. In situ hybridization experiments confirmed that expression of the transcript is undetectable in homozygous mice. (J:65521, J:85366)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acvrl1 Mutation:	26 strains or lines available

Original:	J:65521 Urness LD, et al., Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat Genet. 2000 Nov;26(3):328-31
All:	4 reference(s)