Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Acetm3Unc
Name:	angiotensin I converting enzyme; targeted mutation 3, University of North Carolina
MGI ID:	MGI:2155951
Synonyms:	Tg(Acedup)2Unc, TgH(Acedup)2Unc
Gene:	Ace  Location: Chr11:105858774-105880790 bp, + strand  Genetic Position: Chr11, 68.84 cM
Alliance:	Acetm3Unc page

Germline Transmission:	Earliest citation of germline transmission: J:42519
Parent Cell Line:	BK4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: A gap-repair type targeting vector was used to induce a gene duplication. Two tandem copies of the gene were present in the final allele. Protein activity measurments correlated with gene dosage in serum and lung tissue. (J:42519)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ace Mutation:	54 strains or lines available

Original:	J:42519 Krege JH, et al., Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. Hypertension. 1997 Jan;29(1 Pt 2):150-7
All:	7 reference(s)