Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Als2tm1Hay
Name:	alsin Rho guanine nucleotide exchange factor; targeted mutation 1, M R Hayden
MGI ID:	MGI:3653518
Synonyms:	Als2-
Gene:	Als2  Location: Chr1:59202085-59276390 bp, - strand  Genetic Position: Chr1, 29.33 cM
Alliance:	Als2tm1Hay page

Germline Transmission:	Earliest citation of germline transmission: J:111035
Parent Cell Line:	mEMS128 (ES Cell)
Strain of Origin:	129S1/SvImJ

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A promoter trap strategy was used to replace exons 3 and 4 with an SA-IRES-betageo-pA cassette. The resulting protein encoded from the locus would contain only the five N-terminal amino acids fused to lacZ-neo, thereby inactivating both the full-length and the proposed short form of amyotrophic lateral sclerosis 2 (juvenile) homolog. Absence of protein was confirmed by Western blot analysis of cortex, cerebellum and testis. (J:111035)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Als2 Mutation:	88 strains or lines available

Original:	J:111035 Devon RS, et al., Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9595-600
All:	1 reference(s)