Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nrgntm1Sut
Name:	neurogranin; targeted mutation 1, J Gregor Sutcliffe
MGI ID:	MGI:3628817
Synonyms:	RC3-beta-Gal
Gene:	Nrgn  Location: Chr9:37455789-37464041 bp, - strand  Genetic Position: Chr9, 20.78 cM
Alliance:	Nrgntm1Sut page

Germline Transmission:	Earliest citation of germline transmission: J:109224
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert lacZ into exon 2 in frame such that a fusion protein would be expressed under the control of the endogenous promoter. The resulting protein consists of the first 30 residues of neurogranin followed by beta-gal sequence. The fusion protein does not contain the target of protein kinase C phosphorylation (Ser36) or residues required for binding to calmodulin. (J:109224)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrgn Mutation:	5 strains or lines available

Original:	J:109224 Krucker T, et al., Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus. J Neurosci. 2002 Jul 1;22(13):5525-35
All:	1 reference(s)