Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ctsetm1Kjy
Name:	cathepsin E; targeted mutation 1, Kenji Yamamoto
MGI ID:	MGI:3625688
Synonyms:	CatE-
Gene:	Ctse  Location: Chr1:131566052-131603245 bp, + strand  Genetic Position: Chr1, 57.14 cM, cytoband F
Alliance:	Ctsetm1Kjy page

Germline Transmission:	Earliest citation of germline transmission: J:108745
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced a 3.1-kbp sequence of the gene containing exons 1 to 4. RT-PCR analysis did not detect transcript in spleen tissue from homzygous mutant mice. Immunoblot analysis did not detect protein in homozygous mutant spleen. (J:108745)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctse Mutation:	29 strains or lines available

Original:	J:108745 Tsukuba T, et al., Association of cathepsin E deficiency with development of atopic dermatitis. J Biochem. 2003 Dec;134(6):893-902
All:	13 reference(s)