Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Isl1tm1(cre)Sev Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 1, Sylvia Evans MGI ID: MGI:3623159 Synonyms: Isl1Cre, Isl1Cre, Isl1:Cre Gene: Isl1  Location: Chr13:116434817-116446225 bp, - strand  Genetic Position: Chr13, 64.87 cM, cytoband D2.3 Alliance: Isl1tm1(cre)Sev page

Hindlimb fusion of Bmp4tm4Blh/Bmp4tm4Blh Isl1tm1(cre)Sev/Isl1+ mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:107396
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/Sv

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Isl1tm1(cre)Sev expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Isl1 (MGI:101791)   Mutation details: A cre gene and frt-flanked neo cassette were inserted 6 bp upstream of the translation initiation codon. The neo cassette was removed by germ line, flp-mediated recombination. Expression of cre is regulated by the endogenous promoter. (J:107396)

Activity:	Tissue activity of this recombinase allele
Driver:	Isl1 (mouse) Summary of all recombinase alleles driven by Isl1. Comparative matrix view of recombinase activities Alliance mouse Isl1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

127 assay results 2 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Isl1 Mutation:	33 strains or lines available

Original:	J:107396 Yang L, et al., Isl1Cre reveals a common Bmp pathway in heart and limb development. Development. 2006 Apr;133(8):1575-85
All:	97 reference(s)