Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mylktm1Avs
Name:	myosin, light polypeptide kinase; targeted mutation 1, A V Somlyo
MGI ID:	MGI:3620051
Gene:	Mylk  Location: Chr16:34565580-34822790 bp, + strand  Genetic Position: Chr16, 24.49 cM
Alliance:	Mylktm1Avs page

Germline Transmission:	Earliest citation of germline transmission: J:106058
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A targeting vector was designed to remove a 30-nucleotide promoter sequence containing the AT-rich region and the CArG box, resulting in a complete loss of protein. (J:106058)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mylk Mutation:	103 strains or lines available

Original:	J:106058 Khromov AS, et al., Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2440-5
All:	3 reference(s)