Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Lystbg-J
Name:	lysosomal trafficking regulator; beige Jackson
MGI ID:	MGI:1855969
Synonyms:	bgj
Gene:	Lyst  Location: Chr13:13764982-13953388 bp, + strand  Genetic Position: Chr13, 5.28 cM
Alliance:	Lystbg-J page

Strain of Origin:

C57BL/6J

Allele Type:    Spontaneous Mutation:    Intragenic deletion   Mutation details: This allele is defined by a noncomplementation test with Lystbg. This mutation is the result of a 3 bp in-frame deletion in exon 54 causing the loss of one of the two consecutive isoleucines at codon 3740 and 3741 near the carboxy terminus of the protein. This deletion affects the WD40 domain. (J:7539, J:173521) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

List all tumor models in MMHCdb carrying Lystbg-J

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Lyst Mutation:	225 strains or lines available

Original:	J:5311 Lane PW, et al., Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice. Genetics. 1972 Nov;72(3):451-60
All:	38 reference(s)