Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Otx2tm1(Dkk1)Imat
Name:	orthodenticle homeobox 2; targeted mutation 1, Isao Matsuo
MGI ID:	MGI:3609983
Synonyms:	Otx2ddk
Gene:	Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance:	Otx2tm1(Dkk1)Imat page

Germline Transmission:	Earliest citation of germline transmission: J:103272
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Inserted expressed sequence, Null/knockout) Mutation:    Insertion   Mutation details: The locus was disrupted by the insertion of Dkk1 cDNA and the PGK-neo cassette flanked by two loxP sites. The neomycin cassette was removed by crossing with mice expressing cre recombinase in the germ line. Dkk1 expression was detected in epiblast at E6.5 and in the entire rostral brain region at E7.8, in addition to endogenous expression domains. RT-PCR confirmed the absence of Otx2 transcript in mutant embryos. (J:103272)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:	50 strains or lines available

Original:	J:103272 Kimura-Yoshida C, et al., Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Dev Cell. 2005 Nov;9(5):639-50
All:	1 reference(s)