Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Gnastm5.1Lsw
Name:	GNAS complex locus; targeted mutation 5.1, Lee S Weinstein
MGI ID:	MGI:3609165
Synonyms:	E1fl, Galphasfl, Gnasfl, Gnaslox, Gsalphaf, Gsalphafl
Gene:	Gnas  Location: Chr2:174126113-174188537 bp, + strand  Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
Alliance:	Gnastm5.1Lsw page

Germline Transmission:	Earliest citation of germline transmission: J:102504
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to contain a floxed neo at position -1601 (upstream of exon 1) and a third loxP site downstream of exon 1 at position 419. Crossing with mice expressing cre in the germline removed the neo, leaving exon 1 flanked by loxP sites. (J:99237)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	35 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gnas Mutation:	53 strains or lines available

Original:	J:99237 Chen M, et al., Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7386-91
All:	58 reference(s)