Vkorc1<L128S> Spontaneous Allele Detail MGI Mouse (MGI:3605979)

Vkorc1^L128S
Spontaneous Allele Detail

Summary

Symbol:	Vkorc1^L128S
Name:	vitamin K epoxide reductase complex, subunit 1; Leu128Ser
MGI ID:	MGI:3605979
Gene:	Vkorc1 Location: Chr7:127492235-127494789 bp, - strand Genetic Position: Chr7, 69.81 cM
Alliance:	Vkorc1^L128S page

Mutation
origin

Strain of Origin:

wild

Mutation
description

Allele Type:		Spontaneous
Mutation:		Nucleotide substitutions
		These mice contain a leucine to serine substitution at amino acid position 128. (J:101681)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Vkorc1 Mutation:	6 strains or lines available

Notes

This colony of mice was from CSL in York, UK. A homozygous warfarin-resistant strain was derived by crossing mice of a warfarin-resistant PBI strain, directly descending from wild mice reported in 1976 by Wallace and MacSwiney (J:5635) with warfarin-susceptible mice of a LAC-gray strain. This may by identical to the War marker but analysis is not provided.

References

Original:	J:101681 Pelz HJ, et al., The genetic basis of resistance to anticoagulants in rodents. Genetics. 2005 Aug;170(4):1839-47
All:	1 reference(s)

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