Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Inpp5aGt(OST50073)Lex
Name:	inositol polyphosphate-5-phosphatase A; gene trap OST50073, Lexicon Genetics
MGI ID:	MGI:3604476
Synonyms:	Inpp5aGt694Lex
Gene:	Inpp5a  Location: Chr7:138969025-139159568 bp, + strand  Genetic Position: Chr7, 84.57 cM
Alliance:	Inpp5aGt(OST50073)Lex page

Mutant Cell Line:	OST50073
Germline Transmission:	Earliest citation of germline transmission: J:103485
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Gene trapped (Hypomorph) Mutation:    Insertion of gene trap vector   Mutation details: Retroviral gene trap insertion occurred between exons 8 and 9. The insertion truncated the protein after amino acid 215, removing half of the protein including the predicted active site. RT-PCR analysis of P0 mutants confirmed elimination of wild-type mRNA. No truncated protein was detected by Western blot analysis; however, a small amount of normal protein was detected in both homozygous and heterozygous mutants, probably due to a small amount of splicing around the gene trap. (J:103485, J:249381) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select OST50073 CG503351 (MGI Seq Detail) 3' RACE Chr7:139118092-139147688 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 1 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Inpp5a Mutation:	34 strains or lines available

Original:	J:103485 Lexicon Genetics Inc, NIH initiative supporting placement of Lexicon Genetics, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:	3 reference(s)