Npc2<Gt(LST105)Byg> Gene trapped Allele Detail MGI Mouse (MGI:3587940)

Npc2^{Gt(LST105)Byg}
Gene trapped Allele Detail

Summary

Symbol:	Npc2^{Gt(LST105)Byg}
Name:	NPC intracellular cholesterol transporter 2; gene trap LST105, BayGenomics
MGI ID:	MGI:3587940
Synonyms:	Npc2^{Gt(pGT1TMpfs)1Ucd}, Npc2^{Gt(pGT1TMpfs)1Ucd.Mmc}
Gene:	Npc2 Location: Chr12:84801333-84819886 bp, - strand Genetic Position: Chr12, 39.37 cM
Alliance:	Npc2^{Gt(LST105)Byg} page

Mutation
origin

Mutant Cell Line:	LST105
Germline Transmission:	Earliest citation of germline transmission: J:125609
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT1TMpfs Vector Type: secretory trap

No molecular information is available.

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Npc2 Mutation:	23 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:125609 Schrantz N, et al., The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells. J Exp Med. 2007 Apr 16;204(4):841-52
All:	4 reference(s)

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