Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Tnftm1Pmu
Name:	tumor necrosis factor; targeted mutation 1, Peter J Murray
MGI ID:	MGI:3583916
Synonyms:	Tnfa 3'UTR::Gapdh 3'UTR
Gene:	Tnf  Location: Chr17:35418357-35420983 bp, - strand  Genetic Position: Chr17, 18.59 cM
Alliance:	Tnftm1Pmu page

Germline Transmission:	Earliest citation of germline transmission: J:99724
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted Mutation:    Other   Mutation details: The 3' UTR of Gapdh, bearing two missense mutations in the trimer interface region, was substituted in place of the endogenous 3' UTR via homologous recombination. The loxP flanked neomycin resistance cassette was excised out after selection by transient transfection of the surviving ES cells with pCMB-cre. (J:99724)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:	46 strains or lines available

Original:	J:99724 Murray PJ, The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8686-91
All:	1 reference(s)