Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fgfr1tm1Cxd
Name:	fibroblast growth factor receptor 1; targeted mutation 1, Chu-Xia Deng
MGI ID:	MGI:2153353
Synonyms:	Fgfr1ex3
Gene:	Fgfr1  Location: Chr8:26008808-26067819 bp, + strand  Genetic Position: Chr8, 14.12 cM
Alliance:	Fgfr1tm1Cxd page

Germline Transmission:	Earliest citation of germline transmission: J:54222
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 3, which encodes the first Ig domain contained only in alpha isoforms of the protein. Western blot analysis demonstrated that the alpha isoforms of the protein were not expressed in E9.5 mutant embryos. RT-PCR analysis showed that an increased level of expression of "b" isoform transcripts may partially compensate for loss of alpha isoform expression, and the expression of the "c" isoform is apparently unaffected. (J:54222)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr1 Mutation:	221 strains or lines available

Original:	J:54222 Xu X, et al., Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development. Dev Biol. 1999 Apr 15;208(2):293-306
All:	3 reference(s)