Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Bgntm1Mfy
Name:	biglycan; targeted mutation 1, Marian F Young
MGI ID:	MGI:2153057
Synonyms:	Bgn-/0, Bgn0, bgn-KO
Gene:	Bgn  Location: ChrX:72527208-72539539 bp, + strand  Genetic Position: ChrX, 37.33 cM, cytoband B
Alliance:	Bgntm1Mfy page

Germline Transmission:	Earliest citation of germline transmission: J:49647
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that no transcript was detectable in hemizyogous male mice and western blot analysis showed that the protein was not expressed in hemizygous male mice. (J:49647)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bgn Mutation:	8 strains or lines available

Original:	J:49647 Xu T, et al., Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Nat Genet. 1998 Sep;20(1):78-82
All:	65 reference(s)