Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Abcg2tm1Bsor
Name:	ATP binding cassette subfamily G member 2 (Junior blood group); targeted mutation 1, Brian P Sorrentino
MGI ID:	MGI:3578727
Synonyms:	Abcg2-, Bcrp1-
Gene:	Abcg2  Location: Chr6:58561476-58669436 bp, + strand
Alliance:	Abcg2tm1Bsor page

Germline Transmission:	Earliest citation of germline transmission: J:82049
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3, containing the Walker A motif, and 4 were replaced with a neo. Mutants were demonstrated to lack protein in immunoblots of kidney and liver tissue lysates. (J:82049)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcg2 Mutation:	74 strains or lines available

Original:	J:82049 Zhou S, et al., Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12339-44
All:	9 reference(s)