Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Abca1tm1Jp
Name:	ATP-binding cassette, sub-family A member 1; targeted mutation 1, John S Parks
MGI ID:	MGI:3577723
Synonyms:	Abca1fl, Abca1flox
Gene:	Abca1  Location: Chr4:53030787-53159895 bp, - strand  Genetic Position: Chr4, 28.57 cM, cytoband A5-B3
Alliance:	Abca1tm1Jp page

Germline Transmission:	Earliest citation of germline transmission: J:98093
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion     LoxP sites were inserted to flank exons 45 and 46, which encode the second nucleotide-binding fold. (J:98093)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Abca1 Mutation:	88 strains or lines available

Original:	J:98093 Timmins JM, et al., Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest. 2005 May 2;115(5):1333-1342
All:	64 reference(s)