Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hoxa1tm3.1Mrc
Name:	homeobox A1; targeted mutation 3.1, Mario R Capecchi
MGI ID:	MGI:2151686
Synonyms:	Hoxa1GFPlox
Gene:	Hoxa1  Location: Chr6:52132573-52135299 bp, - strand  Genetic Position: Chr6, 25.4 cM
Alliance:	Hoxa1tm3.1Mrc page

Germline Transmission:	Earliest citation of germline transmission: J:50569
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Insertion of a eGFP gene in-frame to sequences encoding the Hoxa1 gene. An adjacent loxP-flanked neomycin cassette was removed via Cre-mediated recombination in mice in this derivative of Hoxa1tm3Mrc. A Hoxa1-eGFP fusion protein is expressed from this allele in a pattern identical to that predicted by in situ hybridization analysis. (J:50569)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa1 Mutation:	14 strains or lines available

Original:	J:50569 Godwin AR, et al., Detection of targeted GFP-Hox gene fusions during mouse embryogenesis. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13042-7
All:	5 reference(s)