Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Cd274tm1Lex
Name:	CD274 antigen; targeted mutation 1, Lexicon Genetics
MGI ID:	MGI:3528458
Synonyms:	PD-L1CKO
Gene:	Cd274  Location: Chr19:29344855-29365495 bp, + strand  Genetic Position: Chr19, 23.88 cM, cytoband C2
Alliance:	Cd274tm1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:126829
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: By homologous recombination a loxP site was inserted 5' of exon2, followed by a NeoR cassette and a 3' loxP site. The resulting mutant mice were used to create Cd274tm1.1Lex. (J:126829)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd274 Mutation:	71 strains or lines available

Original:	J:126829 Carter LL, et al., PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2007 Jan;182(1-2):124-34
All:	1 reference(s)