Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Icostm1Tkan
Name:	inducible T cell co-stimulator; targeted mutation 1, T Kanai
MGI ID:	MGI:3526880
Synonyms:	ICOS-, ICOS-KO
Gene:	Icos  Location: Chr1:61017086-61039479 bp, + strand  Genetic Position: Chr1, 30.6 cM
Alliance:	Icostm1Tkan page

Germline Transmission:	Earliest citation of germline transmission: J:95728
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin-resistance gene replaced exon 2. Staining of splenic T cells from mutants confirmed the lack of protein expression. (J:95728)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Icos Mutation:	35 strains or lines available

Original:	J:95728 Iiyama R, et al., The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches. Immunol Lett. 2003 Jul 3;88(1):63-70
All:	8 reference(s)