Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ihhtm2Amc
Name:	Indian hedgehog; targeted mutation 2, Andrew P McMahon
MGI ID:	MGI:3526438
Gene:	Ihh  Location: Chr1:74984474-74990831 bp, - strand  Genetic Position: Chr1, 38.55 cM
Alliance:	Ihhtm2Amc page

Germline Transmission:	Earliest citation of germline transmission: J:99641
Parent Cell Line:	AV3 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Frt-flanked neo-tk cassette with a loxP site was introduced into the first intron and another loxP site was introduced into the 5' leader sequence of the first exon by homologous recombination. The neo-tk cassette was excised by transient transfection of properly targeted ES cells with a flpe-expressing plasmid, leaving exon 1 flanked by loxP sites. (J:99641)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ihh Mutation:	22 strains or lines available

Original:	J:99641 Kobayashi T, et al., Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest. 2005 Jul;115(7):1734-42
All:	1 reference(s)