Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tph2Arg447
Name:	tryptophan hydroxylase 2; Arginine 447
MGI ID:	MGI:3521924
Synonyms:	1473G
Gene:	Tph2  Location: Chr10:114914546-115020927 bp, - strand  Genetic Position: Chr10, 63.51 cM
Alliance:	Tph2Arg447 page

Strain of Origin:

various

Allele Type:    Spontaneous Mutation:    Single point mutation   Mutation details: A C-to-G mutation results in a proline to arginine substitution at residue 447 (p.P447R). This variant has been identified in BALB/c and DBA/2 mice from Jackson Laboratory, Charles River, and Hilltop. Levels of mRNA do not seem to be affected but protein activity is reduced 40% in the frontal cortex and striatum of BALB/cJ mice as compared to 129X1/SvJ mice. (J:94745)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tph2 Mutation:	41 strains or lines available

Original:	J:94745 Zhang X, et al., Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science. 2004 Jul 9;305(5681):217
All:	13 reference(s)