Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gabra1tm1Geh
Name:	gamma-aminobutyric acid type A receptor subunit alpha 1; targeted mutation 1, Gregg E Homanics
MGI ID:	MGI:2137418
Gene:	Gabra1  Location: Chr11:42021766-42073757 bp, - strand  Genetic Position: Chr11, 24.97 cM
Alliance:	Gabra1tm1Geh page

Germline Transmission:	Earliest citation of germline transmission: J:70505
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP flanked neomycin and thymidine kinase cassette was inserted 5' to sequences corresponding to nucleotides 1307-1509, and a single loxP site was inserted 3' to these sequences. The loxP flanked neomycin selection cassette was removed in ES cells by transient Cre recombinase expression prior to the production of chimeric mice, leaving a single loxP site in place of the cassette. (J:70505)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabra1 Mutation:	47 strains or lines available

Original:	J:70505 Vicini S, et al., GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. J Neurosci. 2001 May 1;21(9):3009-16
All:	14 reference(s)