Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Mettm2Gvw
Name:	met proto-oncogene; targeted mutation 2, George Vande Woude
MGI ID:	MGI:3521827
Synonyms:	MetY1228C, Y1228Cmu
Gene:	Met  Location: Chr6:17463799-17573979 bp, + strand  Genetic Position: Chr6, 7.83 cM, cytoband A2
Alliance:	Mettm2Gvw page

Germline Transmission:	Earliest citation of germline transmission: J:94722
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Mutation details: A targeting vector was designed to introduce Met exon 14-20 cDNA with a Y1228C mutation downstream of exon 14, changing the TAC codon to TGC. RT-PCR and immunoblotting showed that met RNA and protein expression were equivalent to wild-type. (J:94722)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Mettm2Gvw

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Met Mutation:	82 strains or lines available

Original:	J:94722 Graveel C, et al., Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17198-203
All:	2 reference(s)