Chmp2b<Gt(XL952)Byg> Gene trapped Allele Detail MGI Mouse (MGI:4128363)

Chmp2b^Gt(XL952)Byg
Gene trapped Allele Detail

Summary

Symbol:	Chmp2b^Gt(XL952)Byg
Name:	charged multivesicular body protein 2B; gene trap XL952, BayGenomics
MGI ID:	MGI:4128363
Gene:	Chmp2b Location: Chr16:65336014-65359612 bp, - strand Genetic Position: Chr16, 37.26 cM, cytoband C1.3
Alliance:	Chmp2b^Gt(XL952)Byg page

Mutation
origin

Mutant Cell Line:	XL952
Germline Transmission:	Earliest citation of germline transmission: J:219860
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Hypomorph)

Mutation:

Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap

Mutation details: A gene trap vector (pGT0Lxf) composed of a splice acceptor site (SA), a beta-galactosidase-neomycin fusion protein (b-geo) and a polyA tail (pA) was inserted into intron 2. Quantification of protein levels showed that the knockout is incomplete leading to an 84% reduction in protein levels. (J:221848)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Chmp2b Mutation:	25 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:	6 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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