Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gja1tm1Gfi
Name:	gap junction protein, alpha 1; targeted mutation 1, Glenn I Fishman
MGI ID:	MGI:3051881
Synonyms:	Cx43fl, Cx43flox
Gene:	Gja1  Location: Chr10:56253297-56266519 bp, + strand  Genetic Position: Chr10, 28.64 cM
Alliance:	Gja1tm1Gfi page

Germline Transmission:	Earliest citation of germline transmission: J:91971
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neomycin resistance cassette was inserted into the single intron and a third loxP site was inserted in exon2 just downstream of the open reading frame. The targeting event did not affect gene expression. (J:91971)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gja1 Mutation:	59 strains or lines available

Original:	J:91971 Gutstein DE, et al., Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res. 2001 Feb 16;88(3):333-9
All:	12 reference(s)