Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Runx1tm1Sata
Name:	runt related transcription factor 1; targeted mutation 1, Masanobu Satake
MGI ID:	MGI:1934197
Synonyms:	AML1(-), Runx1-
Gene:	Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance:	Runx1tm1Sata page

Germline Transmission:	Earliest citation of germline transmission: J:50937
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 4 was replaced by a PGK-neo cassette. The deleted region encoded the central portion of the conserved DNA-binding domain. Transcript was undetectable by RT-PCR analysis of extracts from the yolk sacs, livers, and aorta-mesonephros regions of homozygous mutant embryos. (J:50937)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	154 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:	35 strains or lines available

Original:	J:50937 Okada H, et al., AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene. 1998 Nov 5;17(18):2287-93
All:	19 reference(s)