Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myf5tm2(Myog)Jae
Name:	myogenic factor 5; targeted mutation 2, Rudolf Jaenisch
MGI ID:	MGI:1933774
Synonyms:	Myf5myg, Myf5myg-ki
Gene:	Myf5  Location: Chr10:107318769-107321995 bp, - strand  Genetic Position: Chr10, 55.95 cM
Alliance:	Myf5tm2(Myog)Jae page

Germline Transmission:	Earliest citation of germline transmission: J:31611
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Inserted expressed sequence, Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Deletion of all Myf5 coding sequences in exon 1 and replacement with the complete Myog coding region followed by a stop codon. A lox-P flanked neomycin cassette was also inserted downstream of the Myog coding region, but was removed via Cre-mediated recombination in ES cells prior to the generation of chimeric founder mice. This allele expresses a functional Myogenin protein under the control of the Myf5 promoter. (J:31611)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myf5 Mutation:	17 strains or lines available

Original:	J:31611 Wang Y, et al., Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin. Nature. 1996 Feb 29;379(6568):823-5
All:	3 reference(s)