Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Polgtm1Lrsn
Name:	polymerase (DNA directed), gamma; targeted mutation 1, Nils-Goran Larsson
MGI ID:	MGI:3046824
Synonyms:	PolgAmutNeo, PolgloxP
Gene:	Polg  Location: Chr7:79095979-79116110 bp, - strand  Genetic Position: Chr7, 45.04 cM, cytoband E
Alliance:	Polgtm1Lrsn page

Germline Transmission:	Earliest citation of germline transmission: J:91077
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Nucleotide substitutions   Mutation details: An Frt flanked neo was inserted upstream of a floxed exon including an aspartic acid to alanine codon change at position 257 (D257A), in the second exonuclease domain. (J:91077)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Polg Mutation:	57 strains or lines available

Original:	J:91077 Trifunovic A, et al., Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 2004 May 27;429(6990):417-23
All:	3 reference(s)