Neu1<b> Allele Detail MGI Mouse (MGI:3042796)

Neu1^b
Allele Detail

Summary

Symbol:	Neu1^b
Name:	neuraminidase 1; b variant
MGI ID:	MGI:3042796
Synonyms:	Neu-1^b
Gene:	Neu1 Location: Chr17:35150229-35154929 bp, + strand Genetic Position: Chr17, 18.48 cM
Alliance:	Neu1^b page

Mutation
origin

Strain of Origin:

Not Applicable

Mutation
description

Allele Type:		Not Applicable
Mutation:		Nucleotide substitutions
		Mutation details: Sequencing of the b allele revealed 5 nucleotide differences compared to the a allele. These changes alter the amino acid residues 11, 15, 17, 19 and 209 of the encoded protein from Arg, Cys, Val, Cys and Ile to Gly, Tyr, Ala, Arg and Leu, respectively. This encoded protein has greater activity than the protein encoded by the b allele as demonstrated in an in vitro assay. Further studies attributed most of the activity difference to the variation at position 209. (J:43930)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Neu1 Mutation:	26 strains or lines available

Notes

Low activity determined by the Neu1^a allele occurs in the SM/J inbred strain and in wild mice in the area of Ann Arbor, Michigan; all other inbred strains have high activity determined by the Neu1^b allele. Heterozygotes have intermediate activity. Neuraminidase removes extra sialic acid residues from these enzymes. The defective neuraminidase of Neu1^a mice, by failing to remove the extra sialic acid, changes their electrophoretic mobility (J:6480). Level of activity of neuraminidase in activated T lymphocytes is also depressed in Neu1^a/Neu1^a mice (J:7976).

References

Original:	J:6899 Womack JE, et al., Mouse gene for neuraminidase activity (Neu-1) maps to the D end of H-2. Immunogenetics. 1982;16(2):177-80
All:	7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23