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Hand1tm1Cse
Targeted Allele Detail
Nomenclature
Symbol: Hand1tm1Cse
Name: heart and neural crest derivatives expressed 1; targeted mutation 1, Peter Cserjesi
MGI ID: MGI:3042297
Synonyms: Hand1B-gal, hand1lacZ
Gene: Hand1  Location: Chr11:57719539-57722973 bp, - strand  Genetic Position: Chr11, 35.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89474
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first 174 amino acids of exon 1 were replaced with in-frame beta-galactosidase and a neo cassette via homologous recombination. Beta-galactosidase expression recapitulates endogenous protein expression. (J:89474)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 14 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hand1 Mutation:  11 strains or lines available
References
Original:  J:89474 Morikawa Y, et al., Extra-embryonic vasculature development is regulated by the transcription factor HAND1. Development. 2004 May;131(9):2195-204
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory