Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bub1bGt(neo-btk)1Dai
Name:	BUB1B, mitotic checkpoint serine/threonine kinase; gene trap 1, Wei Dai
MGI ID:	MGI:3033386
Synonyms:	BUBR1-, BubR1L
Gene:	Bub1b  Location: Chr2:118428692-118472072 bp, + strand  Genetic Position: Chr2, 59.4 cM
Alliance:	Bub1bGt(neo-btk)1Dai page

Germline Transmission:	Earliest citation of germline transmission: J:88223
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector   Mutation details: The endogenous gene was disrupted by the integration of a gene trap vector into intron 1. The gene trap vector contained a splice acceptor, neo, a polyadenylation signal, PGK-btk, and a a splice donor. (J:88223)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bub1b Mutation:	58 strains or lines available

Original:	J:88223 Wang Q, et al., BUBR1 deficiency results in abnormal megakaryopoiesis. Blood. 2004 Feb 15;103(4):1278-85
All:	5 reference(s)