Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Zic2Ku
Name:	zinc finger protein of the cerebellum 2; kumba
MGI ID:	MGI:1862004
Synonyms:	Gena29, GENA 29, Ku
Gene:	Zic2  Location: Chr14:122712847-122717264 bp, + strand  Genetic Position: Chr14, 65.97 cM
Alliance:	Zic2Ku page

Strain of Origin:

BALB/cAnNCrl

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: The mutation in the kumba mouse was identified as a T to A transversion at coding nucleotide 1105. The resulting missense mutation (p.C369S), is located in the fourth zinc finger domain and the altered cysteine is a canonical residue required to to chelate zinc. Mutations in equivalent residues of other zinc finger proteins predict that this substitution would abolish the function of the zinc finger domain. (J:86841) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	72 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Zic2 Mutation:	41 strains or lines available

Original:	J:63816 Nolan PM, et al., A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet. 2000 Aug;25(4):440-3
All:	12 reference(s)