Foxl2tm1Tre
Targeted Allele Detail
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Symbol: |
Foxl2tm1Tre |
Name: |
forkhead box L2; targeted mutation 1, Mathias Treier |
MGI ID: |
MGI:3029503 |
Synonyms: |
Foxl2lacZ |
Gene: |
Foxl2 Location: Chr9:98837660-98840179 bp, + strand Genetic Position: Chr9, 51.41 cM, cytoband E4
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Alliance: |
Foxl2tm1Tre page
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Germline Transmission: |
Earliest citation of germline transmission:
J:87737
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The sequence encoding amino acids 62-375 was replaced with an in frame nls-lacZ cassette followed by a floxed neomycin resistance gene. This deletes almost the entire the forkhead/winged-helix domain. The neomycin gene was subsequently excised. Western blot analysis of protein extracts from neonatal ovaries detected only lacZ fusion proteins and not the wild-type protein.
(J:87737)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Foxl2 Mutation: |
15 strains or lines available
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Original: |
J:87737 Schmidt D, et al., The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development. 2004 Feb;131(4):933-42 |
All: |
7 reference(s) |
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